I am big fan of MS OneNote. It is the application used most in IHS. It is used to replace Notebooks (known as Jotters in Scotland). I have just come across the the MS Research Roadshow site. This is giving info on lots of things like the worldwidetelescope, and Boku. Another new release from Microsoft Research is InkSeine.
I have been
playing developing my skills with InkSeine. This is a research project for tablet PC's and UMPC's.
I have found the page control to be excellent and the search integration brilliant. but I don't think this will replace OneNote, even for quick notes but I think that the next version of OneNote will have lots of these features built into it.
If you want an intro to what OneNote can do then the video below is good.